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Mozart may reduce seizure frequency in people with epilepsy

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A brand new scientific analysis examine by Dr. Marjan Rafiee and Dr. Taufik Valiante of the Krembil Mind Institute at Toronto Western Hospital, a part of College Well being Community, has discovered that a Mozart composition could scale back seizure frequency in sufferers with epilepsy.

The outcomes of the analysis examine, “The Rhyme and Rhythm of Music in Epilepsy,” was lately printed within the worldwide journal Epilepsia Open. It seems to be on the results of the Mozart melody, “Sonata for Two Pianos in D Main, Ok. 448” on decreasing seizures, as in comparison with one other auditory stimulus — a scrambled model of the unique Mozart composition, with comparable mathematical options, however shuffled randomly and missing any rhythmicity.

“Previously 15 to 20 years, we’ve got realized quite a bit about how listening to one in every of Mozart’s compositions in people with epilepsy seems to exhibit a discount in seizure frequency,” says Dr. Marjan Rafiee, lead creator on the examine. “However, one of many questions that also wanted to be answered was whether or not people would present an identical discount in seizure frequency by listening to a different auditory stimulus — a management piece — as in comparison with Mozart.”

The researchers recruited 13 sufferers to take part within the novel, year-long examine. After three months of a baseline interval, half of the sufferers listened to Mozart’s Sonata as soon as day by day for 3 months, then switched to the scrambled model for 3 months. The others began the intervention by listening to the scrambled model for 3 months, then switched to day by day listening of Mozart.

Sufferers saved “seizure diaries” to doc their seizure frequency throughout the intervention. Their medicines had been saved unchanged throughout the course of the examine.

“Our outcomes confirmed day by day listening to the primary motion of Mozart Ok.448 was related to decreasing seizure frequency in grownup people with epilepsy,” says Dr. Rafiee. “This implies that day by day Mozart listening could also be thought-about as a supplemental therapeutic possibility to scale back seizures in people with epilepsy.”

Epilepsy is the commonest severe neurological dysfunction on this planet, affecting roughly 300,000 Canadians and 50 million individuals worldwide.

Many expertise debilitating seizures. The therapy is commonly a number of anti-seizure medicines. However for 30 per cent of sufferers, the medicines are usually not efficient in controlling their seizures.

“As a surgeon, I’ve the pleasure of seeing people profit from surgical procedure, nevertheless I additionally know effectively these people for whom surgical procedure shouldn’t be an possibility, or those that haven’t benefitted from surgical procedure, so, we’re at all times searching for methods to enhance symptom management, and enhance high quality of life for these with epilepsy,” says Dr. Taufik Valiante, senior creator of the examine and the Director of the Surgical Epilepsy Program at Krembil Mind Institute at UHN and co-Director of CRANIA.

“Like all analysis, ours raises a number of questions that we’re excited to proceed to reply with additional analysis and help from the epilepsy group.”

Whereas these outcomes are promising, the subsequent step is to conduct bigger research with extra sufferers, over an extended time frame.

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Materials offered by University Health Network. Be aware: Content material could also be edited for model and size.

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