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Changes to the brain's reward system may drive overeating in mice

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A mix of innate variations and diet-induced modifications to the reward system could predispose some mice to overeat, in keeping with analysis not too long ago printed in JNeurosci.

Meals is gasoline, however the rising ranges of sugar and fats in fashionable diets make the mind deal with it as a reward. One mind area known as the ventral pallidum (VP) serves as a hub between reward areas and the hypothalamus, a area concerned in feeding conduct. Intertwining meals and reward can result in overeating and could also be a contributing issue to diet-induced weight problems.

Gendelis, Inbar, et al. measured electrical exercise within the VP of mice with limitless entry to excessive fats, excessive sugar meals for a number of months. Consuming the unhealthy weight loss program modified properties of VP neurons: the membrane voltage and firing charge decreased, making it tougher for neurons to ship messages to one another.

The change was extra pronounced within the mice that gained probably the most weight. The identical set bursts strengthened synapses in weight gainers however weakened them in mice that gained the least weight. These signaling variations could also be innate and never attributable to the unhealthy weight loss program itself: the identical plasticity variations seem between mice with pure excessive and low food-seeking conduct even with out publicity to an unhealthy weight loss program.

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Supplies offered by Society for Neuroscience. Be aware: Content material could also be edited for fashion and size.

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