A brand new research of roughly 80,000 sufferers exhibits that folks with Parkinson’s illness (PD) have a 30% greater danger of dying from COVID-19 than individuals with out the neurodegenerative situation.
The brand new evaluation carried out by researchers with College of Iowa Well being Care primarily based on affected person information within the TriNetX COVID-19 analysis community means that Parkinson’s illness is an unbiased danger issue for dying from COVID-19.
The UI analysis group led by neurologists Qiang Zhang, MD, and Nandakumar Narayanan, MD, PhD, recognized the COVID-19 affected person cohort as of July 15 and analyzed the mortality information eight weeks later. They discovered that 5.5% (four,290 out of 78,355) of COVID-19 sufferers with out PD died in comparison with 21.three% (148 of 694) COVID-19 sufferers who additionally had PD.
Nevertheless, the sufferers with PD have been typically older, extra prone to be male, and fewer prone to be African American than the sufferers with out PD. All of those elements additionally improve the chance of loss of life from COVID-19.
So, the UI group used two approaches to account for these variations: logistic regression with age, intercourse, and race as covariates, and matching every PD affected person with 5 non-PD sufferers with the precise age, intercourse, and race, and performing a conditional logistic regression. In each circumstances, the researchers discovered that the chance of dying from COVID-19 was 30% greater for sufferers with PD. The findings are printed within the journal Motion Issues.
“We acknowledge the restrictions of this research; it’s retrospective information from a single database, however we’re assured that these information present that Parkinson’s illness is unbiased danger issue for loss of life in COVID-19,” says Narayanan, UI affiliate professor of neurology and a member of the Iowa Neuroscience Institute. “We imagine this remark shall be of curiosity to clinicians treating sufferers with Parkinson’s illness, and public well being officers.”
The researchers say the findings must also inform sufferers with PD, and their physicians, of the elevated significance of stopping COVID-19 an infection in these sufferers.
“For our personal sufferers, we may give recommendation that it is essential that you simply put on a masks. It is essential that you simply socially distance,” says Zhang, an affiliate within the UI Division of Neurology.
Zhang provides that physicians must also weigh the elevated danger of loss of life from COVID-19 when contemplating how one can look after PD sufferers in individual throughout the pandemic.
A possible cause why PD sufferers have an elevated danger of loss of life from COVID-19 could also be associated to the truth that COVID could cause pneumonia and pneumonia is a number one reason behind loss of life in sufferers with PD. That is partly as a result of Parkinson’s sufferers can have bother swallowing or choking that may trigger aspiration.
“We’re all targeted on COVID proper now, however it is a clear instance of a respiratory sickness that results in elevated mortality [in PD patients]. These findings might also have implications for understanding dangers for PD sufferers from different ailments, together with influenza,” Narayanan says. “I’d advocate a flu vaccine and pneumonia vaccine to attempt to forestall these issues in sufferers with PD.”
Along with Narayanan and Zhang, the UI analysis group included Jordan Schultz, PharmD, Georgina Aldridge, MD, PhD, and Jacob Simmering, PhD.